Technology Process of (2S,3S,4R)-3,4-dihydroxyproline trifluoroacetic acid salt
There total 8 articles about (2S,3S,4R)-3,4-dihydroxyproline trifluoroacetic acid salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) diethyl azodicarboxylate, triphenylphosphine, 2) diphenylphosphoryl azide / 1) THF, 0 deg C, 2) THF, 0 deg C, 1 h
2: 2) sodium borohydride / 1) n-octane, reflux, 4 h, 2) methanol, ice cooling, 30 min
3: 91 percent / triethylamine / CH2Cl2 / 12 h
4: 93 percent / thallium(III) trifluoroacetate / diethyl ether; H2O / 12 h / Ambient temperature
5: 71 percent / sodium periodate, ruthenium trichloride / H2O; CCl4; acetonitrile / 6 h
6: 1 h / Ambient temperature
7: TFA / methanol / 120 h / Ambient temperature
With
ruthenium trichloride; sodium tetrahydroborate; sodium periodate; diphenylphosphoranyl azide; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; thallium(III) trifluoroacetate;
In
methanol; tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile;
- Guidance literature:
-
With
trifluoroacetic acid;
In
methanol;
for 120h;
Yield given;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / triethylamine / CH2Cl2 / 12 h
2: 93 percent / thallium(III) trifluoroacetate / diethyl ether; H2O / 12 h / Ambient temperature
3: 71 percent / sodium periodate, ruthenium trichloride / H2O; CCl4; acetonitrile / 6 h
4: 1 h / Ambient temperature
5: TFA / methanol / 120 h / Ambient temperature
With
ruthenium trichloride; sodium periodate; triethylamine; trifluoroacetic acid; thallium(III) trifluoroacetate;
In
methanol; tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile;
