C₁₂H₁₄BrFO₂SSi

Base Information

• Chemical Name: C₁₂H₁₄BrFO₂SSi
• CAS No.: 2088829-12-1
• Molecular Formula: C₁₂H₁₄BrFO₂SSi
• Molecular Weight: 349.296

Synonyms:

Chemical Property of C₁₂H₁₄BrFO₂SSi

Chemical Property:

• Boiling Point: 374.4±42.0 °C(Predicted)
• Density: 1.42±0.1 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonylFluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Technology Process of C₁₂H₁₄BrFO₂SSi

There total 4 articles about C₁₂H₁₄BrFO₂SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C12H15FO3SSi → C12H14BrFO2SSi (2088829-12-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane;

DOI:10.1002/cbic.201600427

Reference yield:

3-methoxycarbonylbenzenesulphonyl fluoride (124397-36-0) → C12H14BrFO2SSi (2088829-12-1)

Guidance literature:

Multi-step reaction with 4 steps

1: dibromoisocyanuric acid; sulfuric acid / acetonitrile

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride

3: diisobutylaluminium hydride / dichloromethane / -40 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; sulfuric acid; diisobutylaluminium hydride; dibromoisocyanuric acid; triethylamine; triphenylphosphine; In dichloromethane; acetonitrile; 2: |Sonogashira Cross-Coupling;

DOI:10.1002/cbic.201600427

Reference yield:

C8H6BrFO4S → C12H14BrFO2SSi (2088829-12-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride

2: diisobutylaluminium hydride / dichloromethane / -40 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In dichloromethane; 1: |Sonogashira Cross-Coupling;

DOI:10.1002/cbic.201600427

upstream raw materials:

3-methoxycarbonylbenzenesulphonyl fluoride

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