(2S,4R)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid
• CAS No.: 540501-64-2
• Molecular Formula: C₁₃H₂₁NO₆
• Molecular Weight: 287.313
• European Community (EC) Number: 831-650-0
• DSSTox Substance ID: DTXSID20472508
• Wikidata: Q82301478
• Mol file: 540501-64-2.mol

Synonyms:(2S,4R)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid;540501-64-2;(2S,4R)-1-[(tert-butoxy)carbonyl]-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid;(2S,4R)-4-(2-methoxy-2-oxoethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;DTXSID20472508;AKOS016008767;(2S,4R)-1-(Tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylicacid;CS-0453426;EN300-87440;Z291279224

Chemical Property of (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 287.13688739
• Heavy Atom Count: 20
• Complexity: 400

Purity/Quality:

85.0-99.9% ^*data from raw suppliers

(2S,4R)-1-(Tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CC(CC1C(=O)O)CC(=O)OC
• Isomeric SMILES: CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(=O)O)CC(=O)OC

Technology Process of (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid

There total 19 articles about (2S,4R)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Hydroxymethyl-4-[1-methoxycarbonyl-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester (540501-40-4) → (2S,4S)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline (540501-64-2) + (2S,4R)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline (540501-64-2)

Guidance literature:

(S)-2-Hydroxymethyl-4-[1-methoxycarbonyl-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester; With Crabtree's catalyst; hydrogen; In dichloromethane; at 20 ℃; for 18h; under 760 Torr;

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; NaH₂PO₄ buffer; sodium hypochlorite; In water; acetonitrile; at 45 ℃; for 24h; pH=6.6; Title compound not separated from byproducts;

DOI:10.1021/jo034214l

Reference yield:

(S)-2-Hydroxymethyl-4-[1-methoxycarbonyl-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester (540501-40-4) → (2S,4S)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline (540501-64-2) + (2S,4R)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline (540501-64-2)

Guidance literature:

(S)-2-Hydroxymethyl-4-[1-methoxycarbonyl-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester; With Crabtree's catalyst; hydrogen; In dichloromethane; at 20 ℃; for 18h; under 760 Torr;

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; NaH₂PO₄ buffer; sodium hypochlorite; In water; acetonitrile; at 45 ℃; for 24h; pH=6.6; Title compound not separated from byproducts;

DOI:10.1021/jo034214l

Reference yield:

2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester → (2S,4S)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline (540501-64-2) + (2S,4R)-N-tert-butyloxycarbonyl-4-(methoxycarbonyl)methylproline (540501-64-2)

Guidance literature:

2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; NaH₂PO₄ buffer; sodium hypochlorite; In water; acetonitrile; at 45 ℃; for 24h; pH=6.6; Title compound not separated from byproducts;

DOI:10.1021/jo034214l

upstream raw materials:

(S)-2-Hydroxymethyl-4-[1-methoxycarbonyl-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 540501-64-2 (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-(2-METHOXY-2-OXOETHYL)PYRROLIDINE-2-CARBOXYLIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send