4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 952518-97-7
• Molecular Formula: C₉H₇N₅
• Molecular Weight: 185.188
• Hs Code.: 2933998090
• Mol file: 952518-97-7.mol

Synonyms:

Chemical Property of 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazole is used in the preparation of deazapurines such as Ruxolitinib(R702000) which is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.

Technology Process of 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine

There total 5 articles about 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

barictinib → 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (952518-97-7)

Guidance literature:

With hydrogenchloride; In water; at 90 ℃; for 1h;

Reference yield: 71.5%

C12H17N3O3 → 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (952518-97-7)

Guidance literature:

With sodium ethanolate; formamidine hydrochloride; In ethanol; at 75 - 78 ℃; Temperature;

Reference yield: 47.7%

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate (552846-17-0) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (952518-97-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;

upstream raw materials:

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine