6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 189116-10-7
• Molecular Formula: C₅H₄ClN₃S
• Molecular Weight: 173.626
• Hs Code.: 2934999090
• Mol file: 189116-10-7.mol

Synonyms:

Chemical Property of 6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

Purity/Quality:

6-CHLORO-2-METHYLIMIDAZO[2,1-B][1,3,4]THIADIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole

There total 1 articles about 6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C5H7N3O2S*BrH → 6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole (189116-10-7)

Guidance literature:

With trichlorophosphate; for 2h; Reflux;

DOI:10.1039/c4md00228h

Reference yield:

6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole (189116-10-7) → (E)-1-(6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / chloroform / 0 °C / Reflux

2: tetrahydrofuran / 0 - 20 °C

3: 2-iodoxybenzoic acid / dimethyl sulfoxide / 20 °C

4: potassium hydroxide / ethanol; water / 0 - 20 °C

With 2-iodoxybenzoic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform; water; dimethyl sulfoxide; 1: |Vilsmeier Reaction / 2: |Grignard Reaction / 4: |Claisen-Schmidt Condensation;

DOI:10.1039/c4md00228h

Reference yield:

6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole (189116-10-7) → (E)-3-(6-chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / chloroform / 0 °C / Reflux

2: potassium hydroxide / ethanol; water / 0 - 20 °C

With potassium hydroxide; trichlorophosphate; In ethanol; chloroform; water; 1: |Vilsmeier Reaction / 2: |Claisen-Schmidt Condensation;

DOI:10.1039/c4md00228h