1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride

Base Information

• Chemical Name: 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride
• CAS No.: 1391602-71-3
• Molecular Formula: C₉H₁₆N₂O₂*ClH
• Molecular Weight: 220.699
• Mol file: 1391602-71-3.mol

Synonyms:

Chemical Property of 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride

There total 8 articles about 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-2-oxo-4-oxa-1,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester (1391602-70-2) → 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride (1391602-71-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride (1391602-71-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: water; methanol / Cooling with ice

1.2: 72 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / 80 - 108 °C / Industry scale

2.2: 10 - 23 °C / pH 7 - 8 / Industry scale

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 19 - 29 °C / Cooling

3.2: 8 - 56 °C

4.1: dichloromethane; water / 0.58 h / Cooling with ice

5.1: potassium tert-butylate / tert-Amyl alcohol / 0.5 h / 20 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / Inert atmosphere

7.1: potassium tert-butylate / tert-Amyl alcohol / 20 °C / Heating

8.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; water;

Reference yield:

1-benzyl-4-amino-4-piperidinecarboxylic acid (39143-25-4) → 1-methyl-4-oxa-1,9-diaza-spiro[5,5]undecan-2-one hydrochloride (1391602-71-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 19 - 29 °C / Cooling

1.2: 8 - 56 °C

2.1: dichloromethane; water / 0.58 h / Cooling with ice

3.1: potassium tert-butylate / tert-Amyl alcohol / 0.5 h / 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / Inert atmosphere

5.1: potassium tert-butylate / tert-Amyl alcohol / 20 °C / Heating

6.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tert-Amyl alcohol; dichloromethane; water;

upstream raw materials:

1-phenylmethyl-4-piperidone

1-benzyl-4-amino-4-piperidinecarboxylic acid

8-benzyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

(4-amino-1-benzyl-piperidin-4-yl)-methanol

Refernces

• 1、 -. "AMINO-INDOLYL-SUBSTITUTED IMIDAZOLYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS". Page/Page column 67. . Retrieved 2013/11/05.
• 2、 -. "SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS". . . Retrieved 2012/08/08.