[1-(4-Chlorophenyl)cyclohexyl]methanamine

Base Information

• Chemical Name: [1-(4-Chlorophenyl)cyclohexyl]methanamine
• CAS No.: 342425-45-0
• Molecular Formula: C₁₃H₁₈ClN
• Molecular Weight: 223.746
• European Community (EC) Number: 965-394-7
• Mol file: 342425-45-0.mol

Synonyms:[1-(4-chlorophenyl)cyclohexyl]methanamine;342425-45-0;(1-(4-chlorophenyl)cyclohexyl)methanamine;SCHEMBL3663025;NVXHEFNSQQTTPF-UHFFFAOYSA-N;BDBM433573;US10562878, Compound 29;AKOS000345342;CS-0253124;EN300-62475;Z361883836

Chemical Property of [1-(4-Chlorophenyl)cyclohexyl]methanamine

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 223.1127773
• Heavy Atom Count: 15
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

[1-(4-chlorophenyl)cyclohexyl]methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)(CN)C2=CC=C(C=C2)Cl

Technology Process of [1-(4-Chlorophenyl)cyclohexyl]methanamine

There total 3 articles about [1-(4-Chlorophenyl)cyclohexyl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorophenyl)-1-cyclohexanecarbonitrile (64399-28-6) → (1-(4-chlorophenyl)cyclohexyl)methanamine (342425-45-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

Reference yield:

1,5-dibromo-pentane (111-24-0) → (1-(4-chlorophenyl)cyclohexyl)methanamine (342425-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / dimethyl sulfoxide

2: borane-THF

With borane-THF; sodium hydride; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.01.016

Reference yield:

p-chlorobenzyl cyanide (140-53-4) → (1-(4-chlorophenyl)cyclohexyl)methanamine (342425-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / dimethyl sulfoxide

2: borane-THF

With borane-THF; sodium hydride; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.01.016

upstream raw materials:

1-(4-chlorophenyl)-1-cyclohexanecarbonitrile

1,5-dibromo-pentane

p-chlorobenzyl cyanide