(1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

Base Information

Chemical Name:(1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal
CAS No.:66460-05-7
Molecular Formula:C₁₄H₂₀N₂O₈
Molecular Weight:344.321
Hs Code.:

(1<i>S</i>)-6-hydroxy-5-((<i>Z</i>)-2-oxo-propylidene)-1-((1<i>S</i>,2<i>S</i>)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

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Technology Process of (1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

There total 4 articles about (1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66310-62-1,72029-04-0
(1S)-6-hydroxy-5-(2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

: 66460-05-7
(1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

Guidance literature:: With methylamine hydrochloride; sodium cyanoborohydride; In 1,4-dioxane;
DOI:10.7164/antibiotics.32.689

Reference yield:

: 66305-83-7
(1S)-6-hydroxy-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-5,8,10-trione

: 66460-05-7
(1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

Guidance literature:: Multi-step reaction with 2 steps

1: dioxane / 50 °C

2: Na3CN>, MeNH₂*HCl / dioxane

With methylamine hydrochloride; sodium cyanoborohydride; In 1,4-dioxane;
DOI:10.7164/antibiotics.32.689

Reference yield:

: 38129-37-2,48186-38-5,89362-24-3
(1S)-6-hydroxy-5-methylene-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

: 66460-05-7
(1S)-6-hydroxy-5-((Z)-2-oxo-propylidene)-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione (Ξ)-5,6-cyclohemiacetal

Guidance literature:: Multi-step reaction with 3 steps

1: (i) O₃, MeOH, (ii) Me₂S

2: dioxane / 50 °C

3: Na3CN>, MeNH₂*HCl / dioxane

With methylamine hydrochloride; sodium cyanoborohydride; In 1,4-dioxane;
DOI:10.7164/antibiotics.32.689