(1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside

Base Information

• Chemical Name: (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside
• CAS No.: 49662-03-5
• Molecular Formula: C₂₀H₄₀N₄O₁₀
• Molecular Weight: 496.558

Synonyms:

Chemical Property of (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside

Chemical Property:

• Vapor Pressure: 1.1E-26mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside

There total 2 articles about (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

JI-20Ba (S) → G418 (83855-92-9,49662-03-5)

Guidance literature:

With pyridoxal 5'-phosphate; recombinant pyridoxal-phosphate-dependent aminotransferase GenB₁; In aq. buffer; at 37 ℃; pH=8; Enzymatic reaction;

DOI:10.1002/cbic.201500258

Reference yield:

JI-20B (R) → G418 (83855-92-9,49662-03-5)

Guidance literature:

With pyridoxal 5'-phosphate; recombinant pyridoxal-phosphate-dependent aminotransferase GenB₂; In aq. buffer; at 37 ℃; pH=8; Enzymatic reaction;

DOI:10.1002/cbic.201500258

Reference yield:

geneticin (83855-92-9,49662-03-5) → tris-CBz-6-methylparomamine

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 48 h / 30 - 70 °C / Large scale

2: N-ethyl-N,N-diisopropylamine / water; toluene; acetone / 24 h / 30 °C / Large scale

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; water; acetone; toluene;

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