3-phenyl-4-phenylethynylcinnoline

Base Information

• Chemical Name: 3-phenyl-4-phenylethynylcinnoline
• CAS No.: 212778-67-1
• Molecular Formula: C₂₂H₁₄N₂
• Molecular Weight: 306.367
• Mol file: 212778-67-1.mol

Synonyms:

Chemical Property of 3-phenyl-4-phenylethynylcinnoline

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-Phenyl-4-(phenylethynyl)cinnoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-4-phenylethynylcinnoline

There total 3 articles about 3-phenyl-4-phenylethynylcinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

3-phenyl-1,4-di(phenylethynyl)-1,2-dihydrocinnoline (212778-69-3) → 3-phenyl-4-phenylethynylcinnoline (212778-67-1)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 1.5h;

DOI:10.1007/BF02503509

Reference yield:

4-chloro-3-phenylcinnoline (13109-11-0) → 3-phenyl-4-phenylethynylcinnoline (212778-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65.2 percent / Et₃N / Pd(PPh₃)2Cl₂; CuI / 80 - 90 °C

2: 86.3 percent / NaOH / methanol / 1.5 h / 20 °C

With sodium hydroxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In methanol; 1: Condensation / 2: Deacetylation;

DOI:10.1007/BF02503509

Reference yield:

4-bromo-3-phenylcinnoline (157868-96-7) → 3-phenyl-4-phenylethynylcinnoline (212778-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72.3 percent / Et₃N / Pd(PPh₃)2Cl₂; CuI / 3 h / 80 - 90 °C

2: 86.3 percent / NaOH / methanol / 1.5 h / 20 °C

With sodium hydroxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In methanol; 1: Condensation / 2: Deacetylation;

DOI:10.1007/BF02503509

upstream raw materials:

3-phenyl-1,4-di(phenylethynyl)-1,2-dihydrocinnoline

4-chloro-3-phenylcinnoline

4-bromo-3-phenylcinnoline