Technology Process of (E)-1-[2-cyano-2-(pyridin-2-ylsulfonyl)vinyl]urea
There total 3 articles about (E)-1-[2-cyano-2-(pyridin-2-ylsulfonyl)vinyl]urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(pyridin-2-ylsulfonyl)acetonitrile; (Z)-methyl-N-cyanoformimidate;
With
sodium methylate;
In
methanol;
at 22 ℃;
for 4h;
With
hydrogenchloride; water;
In
methanol;
at 22 ℃;
for 2h;
DOI:10.1002/ejoc.201201454
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tetrahydrofuran / 0.25 h / 22 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48.58 h / 0 - 22 °C
3.1: sodium methylate / methanol / 4 h / 22 °C
3.2: 2 h / 22 °C
With
sodium methylate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
3.1: |Knoevenagel Condensation;
DOI:10.1002/ejoc.201201454
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48.58 h / 0 - 22 °C
2.1: sodium methylate / methanol / 4 h / 22 °C
2.2: 2 h / 22 °C
With
sodium methylate; 3-chloro-benzenecarboperoxoic acid;
In
methanol; dichloromethane;
2.1: |Knoevenagel Condensation;
DOI:10.1002/ejoc.201201454