1,1'-Biphenyl]-2,3'-dimethanol

Base Information

• Chemical Name: 1,1'-Biphenyl]-2,3'-dimethanol
• CAS No.: 66888-79-7
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.264
• Mol file: 66888-79-7.mol

Synonyms:

Chemical Property of 1,1'-Biphenyl]-2,3'-dimethanol

Chemical Property:

• Melting Point: 116.5-117.0 °C(Solv: dichloromethane (75-09-2))
• Boiling Point: 405.9±30.0 °C(Predicted)
• PKA: 13.98±0.10(Predicted)
• Density: 1.174±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

[1,1'-Biphenyl]-3,3'-diyldimethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1'-Biphenyl]-2,3'-dimethanol

There total 4 articles about 1,1'-Biphenyl]-2,3'-dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,3'-diformyl-1,1'-biphenyl (19800-47-6) → biphenyl-3,3′-diyldimethanol (66888-79-7)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃; for 2h;

Reference yield: 82.0%

5-formylfurane-2-boronic acid (27329-70-0) + (3-Bromophenyl)methanol (15852-73-0) → biphenyl-3,3′-diyldimethanol (66888-79-7) + 5-(3-(hydroxymethyl)phenyl)furan-2-carbaldehyde (647023-78-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In methanol; at 80 ℃; for 2h; under 0 Torr; Temperature; Pressure;

DOI:10.1039/c4ob01641f

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → biphenyl-3,3′-diyldimethanol (66888-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 85 °C / Inert atmosphere

2: methanol; sodium tetrahydroborate / 2 h / 0 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water;

upstream raw materials:

5-formylfurane-2-boronic acid

(3-Bromophenyl)methanol

m-bromobenzoic aldehyde

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarboxaldehyde

Refernces

• 1、 Trinh, Trieu N.,Hizartzidis, Lacey,Lin, Andrew J. S.,Harman, David G.,McCluskey, Adam,Gordon, Christopher P.. "An efficient continuous flow approach to furnish furan-based biaryls". . p. 9562 - 9571. Retrieved 2015/02/19.