Bremazocine

Base Information

Chemical Name:Bremazocine
CAS No.:71990-00-6
Molecular Formula:C₂₀H₂₉NO₂
Molecular Weight:315.456
Hs Code.:
Mol file:71990-00-6.mol

Synonyms:

Suppliers and Price of Bremazocine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BREMAZOCINE 95.00%
5MG
$ 498.29

Total 2 raw suppliers

Chemical Property of Bremazocine

Chemical Property:

Vapor Pressure:6.28E-09mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

BREMAZOCINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bremazocine

There total 8 articles about Bremazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945843-66-3
2-(4-methoxybenzyl)-1-methyl-2,3-dihydropyridin-4(1H)-one

: 75684-07-0,83829-76-9,71990-00-6
(+/-)-bremazocine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / sodium hydride / tetrahydrofuran / 0.75 h / cooling

2.1: BuLi; i-Pr₂NH / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 68 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 66 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / cooling

4.2: 84 percent / H₂ / Pd/C

5.1: 88 percent / phosphoric acid / 21 h / Heating

6.1: sodium bicarbonate; 1-chloroethyl chloroformate / CHCl₃ / Heating

6.2: 88 percent / conc. hydrochloric acid / methanol / Heating

7.1: BOP; Et₃N

8.1: LiAlH₄

With lithium aluminium tetrahydride; n-butyllithium; carbonochloridic acid 1-chloro-ethyl ester; phosphoric acid; sodium hydride; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; chloroform; 5.1: Grewe cyclization reaction;
DOI:10.1055/s-2007-966026

Reference yield:

: 2-(4-methoxybenzyl)-1,3-dimethyl-2,3-dihydropyridin-4(1H)-one

: 75684-07-0,83829-76-9,71990-00-6
(+/-)-bremazocine

Guidance literature:: Multi-step reaction with 7 steps

1.1: BuLi; i-Pr₂NH / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 68 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 66 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / cooling

3.2: 84 percent / H₂ / Pd/C

4.1: 88 percent / phosphoric acid / 21 h / Heating

5.1: sodium bicarbonate; 1-chloroethyl chloroformate / CHCl₃ / Heating

5.2: 88 percent / conc. hydrochloric acid / methanol / Heating

6.1: BOP; Et₃N

7.1: LiAlH₄

With lithium aluminium tetrahydride; n-butyllithium; carbonochloridic acid 1-chloro-ethyl ester; phosphoric acid; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; chloroform; 4.1: Grewe cyclization reaction;
DOI:10.1055/s-2007-966026

Reference yield:

: 945843-68-5
2-(4-methoxybenzyl)-1,3,3-trimethyl-2,3-dihydropyridin-4(1H)-one

: 75684-07-0,83829-76-9,71990-00-6
(+/-)-bremazocine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 66 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h / cooling

2.2: 84 percent / H₂ / Pd/C

3.1: 88 percent / phosphoric acid / 21 h / Heating

4.1: sodium bicarbonate; 1-chloroethyl chloroformate / CHCl₃ / Heating

4.2: 88 percent / conc. hydrochloric acid / methanol / Heating

5.1: BOP; Et₃N

6.1: LiAlH₄

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; phosphoric acid; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; chloroform; 3.1: Grewe cyclization reaction;
DOI:10.1055/s-2007-966026