ethyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3-thienyl)-4H-pyran-3-carboxylate

Base Information

• Chemical Name: ethyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3-thienyl)-4H-pyran-3-carboxylate
• CAS No.: 445384-12-3
• Molecular Formula: C₂₅H₂₄N₄O₃S₂
• Molecular Weight: 492.623
• Mol file: 445384-12-3.mol

Synonyms:

Chemical Property of ethyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3-thienyl)-4H-pyran-3-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 6-AMINO-5-CYANO-2-(((3-CYANO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA(B)PYRIDIN-2-YL)SULFANYL)METHYL)-4-(3-THIENYL)-4H-PYRAN-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

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MSDS Files:

Useful:

Technology Process of ethyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3-thienyl)-4H-pyran-3-carboxylate

There total 4 articles about ethyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3-thienyl)-4H-pyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C14H13ClN2O3S + 2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile (123413-84-3) → C25H24N4O3S2 (445384-12-3)

Guidance literature:

In ethanol; at 40 - 45 ℃;

DOI:10.1055/s-2006-942433

Reference yield: 65.0%

3-thiophene carboxaldehyde (498-62-4) + malononitrile (109-77-3) + 4-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanyl)-3-oxo-butyric acid ethyl ester (290299-63-7) → C25H24N4O3S2 (445384-12-3)

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1055/s-2006-942433

Reference yield:

3-thiophene carboxaldehyde (498-62-4) → C25H24N4O3S2 (445384-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Et₃N / ethanol

2: 74 percent / ethanol / 40 - 45 °C

With triethylamine; In ethanol;

DOI:10.1055/s-2006-942433

upstream raw materials:

3-thiophene carboxaldehyde

malononitrile

4-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanyl)-3-oxo-butyric acid ethyl ester

2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile

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