12-Chloro-dodec-4-yne

Base Information

• Chemical Name: 12-Chloro-dodec-4-yne
• CAS No.: 80436-73-3
• Molecular Formula: C₁₂H₂₁Cl
• Molecular Weight: 200.752
• Mol file: 80436-73-3.mol

Synonyms:

Chemical Property of 12-Chloro-dodec-4-yne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-Chloro-dodec-4-yne

There total 2 articles about 12-Chloro-dodec-4-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propyl bromide (106-94-5) + C9H14ClLi (80436-71-1) → 12-Chloro-dodec-4-yne (80436-73-3) + 12-Bromo-dodec-4-yne (80436-74-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; diethyl ether; benzene; at 20 ℃; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1007/BF00949490

Reference yield:

1,1,9-trichloro-1-nonene (3930-10-7) → 12-Chloro-dodec-4-yne (80436-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: n-PrLi / diethyl ether; tetrahydrofuran; benzene / -20 -> 20 deg C, 1.5 h

2: HMPA / diethyl ether; tetrahydrofuran; benzene / 12 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; propyllithium; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1007/BF00949490

upstream raw materials:

propyl bromide

C₉H₁₄ClLi

1,1,9-trichloro-1-nonene

Refernces