N-[3(R)-(3,4-Dichlorophenyl)-5-[4-[3(R)-(N-methylcarbamoylmethyl)-2-oxopiperidin-1-yl]piperidin-1-yl]-2(Z)-(methoxyimino)pentyl]-N-methyl-3,5-dichlorobenzamide

Base Information

• Chemical Name: N-[3(R)-(3,4-Dichlorophenyl)-5-[4-[3(R)-(N-methylcarbamoylmethyl)-2-oxopiperidin-1-yl]piperidin-1-yl]-2(Z)-(methoxyimino)pentyl]-N-methyl-3,5-dichlorobenzamide
• CAS No.: 226915-43-1
• Molecular Formula: C₃₃H₄₁Cl₄N₅O₄
• Molecular Weight: 713.532
• Mol file: 226915-43-1.mol

Synonyms:

Chemical Property of N-[3(R)-(3,4-Dichlorophenyl)-5-[4-[3(R)-(N-methylcarbamoylmethyl)-2-oxopiperidin-1-yl]piperidin-1-yl]-2(Z)-(methoxyimino)pentyl]-N-methyl-3,5-dichlorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3(R)-(3,4-Dichlorophenyl)-5-[4-[3(R)-(N-methylcarbamoylmethyl)-2-oxopiperidin-1-yl]piperidin-1-yl]-2(Z)-(methoxyimino)pentyl]-N-methyl-3,5-dichlorobenzamide

There total 56 articles about N-[3(R)-(3,4-Dichlorophenyl)-5-[4-[3(R)-(N-methylcarbamoylmethyl)-2-oxopiperidin-1-yl]piperidin-1-yl]-2(Z)-(methoxyimino)pentyl]-N-methyl-3,5-dichlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichlorobenzoyl chloride (2905-62-6) → 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide (226915-43-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 97 percent / pyridine / CH₂Cl₂

2.1: 80 percent / hydrofluoric acid / acetonitrile

3.1: 100 percent / mercuric perchlorate; CaCO₃; H₂O / tetrahydrofuran

4.1: 28 percent / pyridine

5.1: 100 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂

6.1: NaCNBH₃ / 2,2,2-trifluoro-ethanol

6.2: chiral HPLC

With pyridine; mercury(II) perchlorate; oxalyl dichloride; hydrogen fluoride; water; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; calcium carbonate; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; acetonitrile;

DOI:10.1016/S0960-894X(02)00340-2

Reference yield:

3,5-dichlorobenzoyl chloride (2905-62-6) → 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide (226915-43-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 97 percent / pyridine / CH₂Cl₂

2.1: 80 percent / hydrofluoric acid / acetonitrile

3.1: 100 percent / mercuric perchlorate; CaCO₃; H₂O / tetrahydrofuran

4.1: 28 percent / pyridine

5.1: 100 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂

6.1: NaCNBH₃ / 2,2,2-trifluoro-ethanol

6.2: chiral HPLC

With pyridine; mercury(II) perchlorate; oxalyl dichloride; hydrogen fluoride; water; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; calcium carbonate; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; acetonitrile;

DOI:10.1016/S0960-894X(02)00340-2

Reference yield:

3,5-dichlorobenzoyl chloride (2905-62-6) → 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide (226915-43-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 97 percent / pyridine / CH₂Cl₂

2.1: 80 percent / hydrofluoric acid / acetonitrile

3.1: 100 percent / mercuric perchlorate; CaCO₃; H₂O / tetrahydrofuran

4.1: 28 percent / pyridine

5.1: 100 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂

6.1: NaCNBH₃ / 2,2,2-trifluoro-ethanol

6.2: chiral HPLC

With pyridine; mercury(II) perchlorate; oxalyl dichloride; hydrogen fluoride; water; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; calcium carbonate; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; acetonitrile;

DOI:10.1016/S0960-894X(02)00340-2

upstream raw materials:

N-methyl-2-(2-oxo-[1,4']bipiperidinyl-3-yl)-acetamide

3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-oxo-pentyl]-N-methyl-benzamide

3,5-dichlorobenzoyl chloride

{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-yl}-methanol