C₁₁H₁₆Cl₂O₂

Base Information

Chemical Name:C₁₁H₁₆Cl₂O₂
CAS No.:121523-54-4
Molecular Formula:C₁₁H₁₆Cl₂O₂
Molecular Weight:251.153
Hs Code.:

C<sub>11</sub>H<sub>16</sub>Cl<sub>2</sub>O<sub>2</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₁H₁₆Cl₂O₂

Chemical Property:

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Technology Process of C₁₁H₁₆Cl₂O₂

There total 11 articles about C₁₁H₁₆Cl₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70870-94-9
(1S,2R,3R,5R)-2-ethoxycarbonyl-7,7-ethylenedioxy-3-hydroxy-bicyclo<3.3.0>octane

: 121478-55-5,121523-54-4
C₁₁H₁₆Cl₂O₂

Guidance literature:: Multi-step reaction with 9 steps

1: PPTS

2: LAH

3: imidazole / dimethylformamide / 0.5 h / Ambient temperature

4: AcOH, H₂O / tetrahydrofuran / 1.5 h / 90 °C

5: p-TsOH*H₂O / CH₂Cl₂ / 0.33 h / Ambient temperature

6: 1.) NaH / 1.) DMSO, 25 deg C, 30 min, 2.) DMSO, 1 h, RT

7: p-TsOH*H₂O / methanol / 4 h / Ambient temperature

8: NaOH / benzyltriethylammonium chloride / 0.17 h / Ambient temperature

9: (n-Bu)4 NF / tetrahydrofuran / 0.25 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; acetic acid; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(88)90019-1

Reference yield:

: 70893-59-3,74923-22-1,105455-68-3,105455-69-4
(1S,5R)-2-ethoxycarbonyl-7,7-ethylenedioxy-bicyclo<3.3.0>octan-3-one

: 121478-55-5,121523-54-4
C₁₁H₁₆Cl₂O₂

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / NaBH₄

2: PPTS

3: LAH

4: imidazole / dimethylformamide / 0.5 h / Ambient temperature

5: AcOH, H₂O / tetrahydrofuran / 1.5 h / 90 °C

6: p-TsOH*H₂O / CH₂Cl₂ / 0.33 h / Ambient temperature

7: 1.) NaH / 1.) DMSO, 25 deg C, 30 min, 2.) DMSO, 1 h, RT

8: p-TsOH*H₂O / methanol / 4 h / Ambient temperature

9: NaOH / benzyltriethylammonium chloride / 0.17 h / Ambient temperature

10: (n-Bu)4 NF / tetrahydrofuran / 0.25 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; acetic acid; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(88)90019-1

Reference yield:

: 70871-22-6
(1S,2R,3R,5R)-2-hydroxymethyl-3-(tetrahydropyran-2-yl)oxy-7,7-ethylenedioxybicyclo<3.3.0>octane

: 121478-55-5,121523-54-4
C₁₁H₁₆Cl₂O₂

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide / 0.5 h / Ambient temperature

2: AcOH, H₂O / tetrahydrofuran / 1.5 h / 90 °C

3: p-TsOH*H₂O / CH₂Cl₂ / 0.33 h / Ambient temperature

4: 1.) NaH / 1.) DMSO, 25 deg C, 30 min, 2.) DMSO, 1 h, RT

5: p-TsOH*H₂O / methanol / 4 h / Ambient temperature

6: NaOH / benzyltriethylammonium chloride / 0.17 h / Ambient temperature

7: (n-Bu)4 NF / tetrahydrofuran / 0.25 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; tetrabutyl ammonium fluoride; water; sodium hydride; toluene-4-sulfonic acid; acetic acid; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(88)90019-1