Technology Process of (R)-1-(7-bromoquinolin-2-yl)ethan-1-ol
There total 3 articles about (R)-1-(7-bromoquinolin-2-yl)ethan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium formate; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine;
In
tetrahydrofuran;
at 40 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 5 h / 100 °C
1.2: 1 h
2.1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; sodium formate / tetrahydrofuran / 4 h / 40 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium formate; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine;
In
tetrahydrofuran; 1,4-dioxane;
2.1: |Noyori Asymmetric Hydrogenation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetyl chloride; sodium iodide / acetonitrile / 3 h / 80 °C / Sealed tube
2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 5 h / 100 °C
2.2: 1 h
3.1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; sodium formate / tetrahydrofuran / 4 h / 40 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium formate; acetyl chloride; sodium iodide; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine;
In
tetrahydrofuran; 1,4-dioxane; acetonitrile;
3.1: |Noyori Asymmetric Hydrogenation;
