(E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

Base Information

Chemical Name:(E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt
CAS No.:1370023-80-5
Molecular Formula:C₃₄H₃₂BrN₆O₃*Na
Molecular Weight:675.56
Hs Code.:

(E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

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Chemical Property of (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

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Technology Process of (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

There total 15 articles about (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid

: 1370023-80-5
(E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 25 - 35 ℃; for 1.5h; pH=9 - 11;

Reference yield:

: 2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxylic acid

: 1370023-80-5
(E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 1-methyl-pyrrolidin-2-one / tetrahydrofuran / 1 h / 25 °C

1.2: 25 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 65 - 68 °C

2.2: 2.5 h / 60 °C

3.1: sodium hydroxide / water; tetrahydrofuran / 1.5 h / 25 - 35 °C / pH 9 - 11

With thionyl chloride; water; sodium hydroxide; 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; methanol; water;

Reference yield:

: 494799-38-1
3-cyclopentyl-1-methylindole-6-carboxylic acid methyl ester

: 1370023-80-5
(E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid sodium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: 0.5 h / 65 °C

2.1: bromine / acetonitrile / -6 °C

3.1: triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II) / acetonitrile / 6 h / 81 - 83 °C / Inert atmosphere

3.2: 2 h / 76 - 77 °C / Inert atmosphere

3.3: 70 °C

4.1: sodium hydroxide; water / 1-methyl-pyrrolidin-2-one / 10 h / 50 - 53 °C / Inert atmosphere

4.2: 0.5 h / 45 °C / pH 5.5 - 7.5

5.1: thionyl chloride / 1-methyl-pyrrolidin-2-one / tetrahydrofuran / 1 h / 25 °C

5.2: 25 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 65 - 68 °C

6.2: 2.5 h / 60 °C

7.1: sodium hydroxide / water; tetrahydrofuran / 1.5 h / 25 - 35 °C / pH 9 - 11

With thionyl chloride; water; bromine; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; sodium hydroxide; 1-methyl-pyrrolidin-2-one; trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; acetonitrile; 3.1: Suzuki Coupling / 3.2: Suzuki Coupling;