28(R)-methoxy rapamycin

Base Information

Chemical Name:28(R)-methoxy rapamycin
CAS No.:159351-88-9
Molecular Formula:C₅₂H₈₁NO₁₃
Molecular Weight:928.214
Hs Code.:

Synonyms:

Suppliers and Price of 28(R)-methoxy rapamycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
28-O-Methyl-rapamycin
1mg
$ 185.00

Medical Isotopes, Inc.
28-O-Methyl-rapamycin
10 mg
$ 2200.00

Total 6 raw suppliers

Chemical Property of 28(R)-methoxy rapamycin

Chemical Property:

Melting Point:>102°C (dec.)

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

28-O-Methyl-rapamycin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 28-O-Methyl-rapamycin is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

Technology Process of 28(R)-methoxy rapamycin

There total 6 articles about 28(R)-methoxy rapamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 28(R)-methoxy 40(R)-O-tert-butyldimethylsilyl rapamycin

: 159351-88-9
28(R)-methoxy rapamycin

Guidance literature:: With sulfuric acid; In methanol; at -20 ℃; for 48h;

Reference yield: 51.0%

: C₅₈H₉₅NO₁₃Si

: 159351-88-9
C₅₂H₈₁NO₁₃

Guidance literature:: With pyridine hydrogenfluoride; In acetonitrile; at 0 ℃;
DOI:10.1021/ja954328h

Reference yield:

: 53123-88-9
sirolimus

: 159351-88-9
C₅₂H₈₁NO₁₃

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

2: 60 percent / CH₂Cl₂ / Ambient temperature

3: 51 percent / HF*pyridine / acetonitrile / 0 °C

With 2,6-dimethylpyridine; pyridine hydrogenfluoride; In dichloromethane; acetonitrile;
DOI:10.1021/ja954328h