Technology Process of N1-(2-(2-Chlorophenylthio)Benzyl)-N2,N2-Dimethylethane-1,2-Diamine
There total 5 articles about N1-(2-(2-Chlorophenylthio)Benzyl)-N2,N2-Dimethylethane-1,2-Diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-((2-chlorophenyl)thio)-N-(2-(dimethylamino)ethyl)benzamide;
With
sodium tetrahydroborate; boron trifluoride diethyl etherate;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
In
tetrahydrofuran;
for 3h;
Reflux;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01134
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene / 4.17 h / 10 - 20 °C
2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2.2: 3 h / Reflux; Inert atmosphere
With
sodium tetrahydroborate; boron trifluoride diethyl etherate;
In
tetrahydrofuran; toluene;
DOI:10.1021/acs.jmedchem.7b01134
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; copper / N,N-dimethyl-formamide / 12 h / 120 °C
2.1: thionyl chloride / toluene / 2 h / 20 - 100 °C
3.1: toluene / 4.17 h / 10 - 20 °C
4.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
4.2: 3 h / Reflux; Inert atmosphere
With
sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; copper; potassium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.7b01134
