N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

Base Information

Chemical Name:N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine
CAS No.:1976050-09-5
Molecular Formula:C₁₆H₁₀F₃N₅
Molecular Weight:329.284
Hs Code.:

Synonyms:

Suppliers and Price of N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
Valiglurax NEW
50 mg
$ 507.50

Biosynth Carbosynth
Valiglurax NEW
10 mg
$ 145.00

AK Scientific
Valiglurax
50mg
$ 735.00

Total 7 raw suppliers

Chemical Property of N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

Chemical Property:

Boiling Point:549.9±45.0 °C(Predicted)
Density:1.530±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Valiglurax NEW ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

There total 10 articles about N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

: 1976050-09-5
N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

Guidance literature:: With trifluoroacetic acid; In toluene; Autoclave;

Reference yield:

: 215797-81-2
N-(3-bromophenethyl)-2,2,2-trifluoroacetamide

: 1976050-09-5
N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 2-chloropyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -78 - 160 °C / Inert atmosphere; Microwave irradiation

2: manganese(IV) oxide / m-xylene / 130 °C

3: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.55 h / 20 - 140 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid / toluene / Autoclave

With 2-chloropyridine; manganese(IV) oxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trifluoromethylsulfonic anhydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; m-xylene; toluene;

Reference yield:

: 58971-11-2
2-(3-bromophenyl)ethanamine

: 1976050-09-5
N-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-(trifluoromethyl)isoquinolin-6-amine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid; triethylamine / dichloromethane / 1 h

2: 2-chloropyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -78 - 160 °C / Inert atmosphere; Microwave irradiation

3: manganese(IV) oxide / m-xylene / 130 °C

4: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.55 h / 20 - 140 °C / Microwave irradiation; Inert atmosphere

5: trifluoroacetic acid / toluene / Autoclave

With 2-chloropyridine; manganese(IV) oxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trifluoromethylsulfonic anhydride; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; m-xylene; toluene;