(2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
CAS No.:2010159-60-9
Molecular Formula:C₂₈H₄₁N₅O₆S
Molecular Weight:575.729
Hs Code.:2934100090

(2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Synonyms:

Suppliers and Price of (2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
(S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase)
002
$ 950.00

DC Chemicals
(S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase)
001
$ 550.00

BroadPharm
(S,R.S)-AHPC-PEG2-aminehydrochloridesalt 98%
100 MG
$ 540.00

Total 9 raw suppliers

Chemical Property of (2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Chemical Property:

Boiling Point:856.9±65.0 °C(Predicted)
Density:1.249±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description (S, R, S)-AHPC-PEG2-amine is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG2 unit to empower drug research & discovery. It is reactive with NHS ester or carboxylic acid.

Technology Process of (2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

There total 16 articles about (2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: tert-butyl (2-(2-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3.3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)ethoxy)ethyl)carbamate

: 2010159-60-9
(2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 3h;

Reference yield:

: 108466-89-3
N-(tert-butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid

: 2010159-60-9
(2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 1 h / 25 °C

2: hydrogenchloride / 1,4-dioxane; water / 2 h / 25 °C

With hydrogenchloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1448297-52-6
(2S,4R)-1-[(2S)-2-azanyl-3,3-dimethylbutanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanylpyrrolidine-2-carboxamide

: 2010159-60-9
(2S,4R)-1-[(2S)-2-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-3,3-dimethylbutanoyl]-4- hydroxy-N-[[4-(4-methyl-13-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 1 h / 25 °C

2: hydrogenchloride / 1,4-dioxane; water / 2 h / 25 °C

With hydrogenchloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;