N-[2-(2-methoxyphenoxy)ethyl]acetamide

Base Information

• Chemical Name: N-[2-(2-methoxyphenoxy)ethyl]acetamide
• CAS No.: 293738-17-7
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 293738-17-7.mol

Synonyms:

Chemical Property of N-[2-(2-methoxyphenoxy)ethyl]acetamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-[2-(2-Methoxyphenoxy)ethyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-[2-(2-Methoxyphenoxy)ethyl]acetamide, is a building block in the synthesis of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.

Technology Process of N-[2-(2-methoxyphenoxy)ethyl]acetamide

There total 2 articles about N-[2-(2-methoxyphenoxy)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-methyl-4,5-dihydro-1,3-oxazole (1120-64-5,26375-28-0) + 2-methoxy-phenol (90-05-1) → N-[2-(2-methoxyphenoxy)ethyl]acetamide (293738-17-7)

Guidance literature:

at 160 ℃; for 20h; Neat (no solvent);

Reference yield: 40.0%

2-(2-methoxy-phenoxy)-ethylamine (1836-62-0) + acetic anhydride (108-24-7) → N-[2-(2-methoxyphenoxy)ethyl]acetamide (293738-17-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.06.100

upstream raw materials:

2-methyl-4,5-dihydro-1,3-oxazole

2-methoxy-phenol

2-(2-methoxy-phenoxy)-ethylamine

acetic anhydride

Refernces

• 1、 Carocci, Alessia,Catalano, Alessia,Lovece, Angelo,Lentini, Giovanni,Duranti, Andrea,Lucini, Valeria,Pannacci, Marilou,Scaglione, Francesco,Franchini, Carlo. "Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors". experimental part. p. 6496 - 6511. Retrieved 2010/10/02.