2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride

Base Information

• Chemical Name: 2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride
• CAS No.: 99944-02-2
• Molecular Formula: C₁₄H₁₉NO₂*ClH
• Molecular Weight: 269.771
• European Community (EC) Number: 874-045-7

Synonyms:99944-02-2;2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride;(1-benzyl-4-piperidinyl)acetic acid hydrochloride;(1-benzylpiperidin-4-yl)acetic acid hydrochloride;2-(1-benzylpiperidin-4-yl)acetic acid;hydrochloride;2-(1-Benzylpiperidin-4-yl)aceticacidhydrochloride;SCHEMBL9537230;GBHAAUKHXCERKW-UHFFFAOYSA-N;ZDA94402;MFCD13250102;AKOS015893257;BS-39611;CS-0257565;G37406;EN300-6738838;1-(phenylmethyl)-4-piperidineacetic acid hydrochloride

Chemical Property of 2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride

Chemical Property:

• Melting Point: 137-145 °C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 269.1182566
• Heavy Atom Count: 18
• Complexity: 241

Purity/Quality:

99% ^*data from raw suppliers

2-(1-Benzylpiperidin-4-yl)aceticacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCC1CC(=O)O)CC2=CC=CC=C2.Cl

Technology Process of 2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride

There total 8 articles about 2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl N-benzyl-piperidin-4-yl-acetate hydrochloride → 2-(1-benzylpiperidin-4-yl)acetic acid hydrochloride (99944-02-2)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1081/SCC-120021515

Reference yield:

ethyl [1-(phenylmethyl)-4-piperidinyl]acetate hydrochloride → 2-(1-benzylpiperidin-4-yl)acetic acid hydrochloride (99944-02-2)

Guidance literature:

With hydrogenchloride;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 2-(1-benzylpiperidin-4-yl)acetic acid hydrochloride (99944-02-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 90 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: NaBH₄ / CH₂Cl₂; acetic acid / 0 - 20 °C

3.1: NaBH₄ / CH₂Cl₂ / 5 h / Heating

4.1: aq. HCl / methanol

5.1: 97 percent / aq. NaOH / 80 h / Heating

6.1: aq. HCl / 48 h / Heating

6.2: 75 percent / aq. HCl / 20 °C

7.1: 85 percent / aq. HCl / 6 h / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; In methanol; dichloromethane; acetic acid;

DOI:10.1081/SCC-120021515

upstream raw materials:

1-phenylmethyl-4-piperidone

N-benzyl-piperidin-4-yl-malonitrile

2-(1-benzylpiperidin-4-ylidene)malononitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 99944-02-2 2-(1-benzylpiperidin-4-yl)acetic acid hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send