1,2-diazepine dihydrochloride

Base Information

• Chemical Name: 1,2-diazepine dihydrochloride
• CAS No.: 151540-98-6
• Molecular Formula: C₅H₁₂N₂*2ClH
• Molecular Weight: 173.086
• Mol file: 151540-98-6.mol

Synonyms:

Chemical Property of 1,2-diazepine dihydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1,2-Diazepanedihydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-diazepine dihydrochloride

There total 3 articles about 1,2-diazepine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

→ 1,2-diazepine dihydrochloride (151540-98-6)

Guidance literature:

Reference yield: 89.0%

di-tert-butyl 1,2-diazepane-1,2-dicarboxylate (939964-15-5) → 1,2-diazepine dihydrochloride (151540-98-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2007.01.111

Reference yield:

1,5-dibromo-pentane (111-24-0) → 1,2-diazepine dihydrochloride (151540-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / aq. NaOH; Et₄NBr / toluene / 12 h / Heating

2: 89 percent / HCl / dioxane; CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; sodium hydroxide; tetraethylammonium bromide; In 1,4-dioxane; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2007.01.111

upstream raw materials:

di-tert-butyl 1,2-diazepane-1,2-dicarboxylate

1,5-dibromo-pentane

Refernces

• 1、 -. "NOVEL CATHEPSIN C INHIBITORS AND THEIR USE". Page/Page column 22. . Retrieved 2010/11/23.