RBN-2397

Base Information

• Chemical Name: RBN-2397
• CAS No.: 2381037-82-5
• Molecular Formula: C₂₀H₂₃F₆N₇O₃
• Molecular Weight: 523.438

Synonyms:

Chemical Property of RBN-2397

Chemical Property:

• Density: 1.53±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

RBN-2397 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: RBN-2397 can be prepared as a PARP7 inhibitor, which is useful for treating cancer.

Technology Process of RBN-2397

There total 15 articles about RBN-2397 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

(S)-2-(4-methoxybenzyl)-5-(1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-ylamino)-4-(trifluoromethyl)pyridazin-3(2H)-one → RBN-2397 (2381037-82-5)

Guidance literature:

With trifluorormethanesulfonic acid; trifluoroacetic acid; at 25 ℃; for 2h;

Reference yield: 61.2%

trifluorormethanesulfonic acid (1493-13-6) + (S)-2-(4-methoxybenzyl)-5-(1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-ylamino)-4-(trifluoromethyl)pyridazin-3(2H)-one → RBN-2397 (2381037-82-5)

Guidance literature:

With trifluoroacetic acid; at 25 ℃; for 2h;

Reference yield: 20.0%

2-(piperazin-1-yl)-5-(trifluoromethyl)pyrimidine (745066-18-6) + 3-[(2S)-2-[[6-oxo-5-(trifluoromethyl)-1,6-dihydropyridazin-4-yl]amino]propoxy]propanoic acid → RBN-2397 (2381037-82-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

upstream raw materials:

2-(piperazin-1-yl)-5-(trifluoromethyl)pyrimidine

5-chloro-2-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-2,3-dihydropyridazin-3-one

2-chloro-5-(trifluoromethyl)pyrimidine

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