Technology Process of (3R,4R)-(-)-4-fluoro-6-methyl-3-propyl-1,2,3,4-tetrahydroisoquinoline
There total 6 articles about (3R,4R)-(-)-4-fluoro-6-methyl-3-propyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; trichloroisocyanuric acid; hydrogen; (R)-segphos;
In
1,4-dioxane; isopropyl alcohol;
at 30 ℃;
for 20h;
under 31029.7 Torr;
enantioselective reaction;
Autoclave;
DOI:10.1021/acs.orglett.7b02502
- Guidance literature:
-
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3-dichloro-5,5-dimethylhydantoin; hydrogen; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane);
In
1,4-dioxane; isopropyl alcohol;
at 30 ℃;
for 20h;
under 30003 Torr;
enantioselective reaction;
DOI:10.1039/c3cc45341c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 20 °C
2: lithium carbonate; silver nitrate; N-fluorobis(benzenesulfon)imide / N,N-dimethyl acetamide / 20 °C
3: hydrogenchloride / diethyl ether / 0.01 h / 20 °C
4: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane); 1,3-dichloro-5,5-dimethylhydantoin / 1,4-dioxane; isopropyl alcohol / 20 h / 30 °C / 30003 Torr
With
hydrogenchloride; bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3-dichloro-5,5-dimethylhydantoin; hydrogen; lithium carbonate; silver nitrate; N-fluorobis(benzenesulfon)imide; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane);
In
1,4-dioxane; diethyl ether; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1039/c3cc45341c
