N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide

Base Information

Chemical Name:N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide
CAS No.:314054-36-9
Molecular Formula:C₁₆H₁₉N₃O₃
Molecular Weight:301.345
Hs Code.:
UNII:JC3KZQ72GW
DSSTox Substance ID:DTXSID401032115
Nikkaji Number:J3.050.406B
Wikidata:Q19597510
Wikipedia:HIOC

Synonyms:N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide

Suppliers and Price of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
HIOC
2.5mg
$ 140.00

Tocris
HIOC ≥98%(HPLC)
50
$ 579.00

Tocris
HIOC ≥98%(HPLC)
10
$ 137.00

Total 2 raw suppliers

Chemical Property of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide

Chemical Property:

Boiling Point:746.1±60.0 °C(Predicted)
Density:1.326±0.06 g/cm3(Predicted)
XLogP3:1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:301.14264148
Heavy Atom Count:22
Complexity:429

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

HIOC ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(C(=O)NC1)C(=O)NCCC2=CNC3=C2C=C(C=C3)O
Uses HIOC is a selective tropomyosin-related kinase receptor B (TrkB) receptor agonist used in the treatment of early brain injury following subarachnoid hemorrhage (SAH). In addition it protects retinas from retinal degredation.

Technology Process of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide

There total 5 articles about N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₁₁N₃O₂

: 153-98-0,21591-86-6
serotonin hydrochloride

: 314054-36-9
N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide

Guidance literature:: With pyridine; triethylamine; In dichloromethane; at 20 ℃; for 3h; chemoselective reaction;
DOI:10.1016/j.tetlet.2015.01.167

Reference yield:

: 41888-21-5
3-carboxy-2-piperidone

: 314054-36-9
N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: pyridine; triethylamine / dichloromethane / 3 h / 20 °C

With pyridine; triethylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2015.01.167

Reference yield:

: 3731-16-6
3-carboethoxy-2-pyridone

: 314054-36-9
N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: pyridine; triethylamine / dichloromethane / 3 h / 20 °C

With pyridine; triethylamine; potassium hydroxide; In dichloromethane; water;
DOI:10.1016/j.tetlet.2015.01.167