21-Hydroxy DeschloroMoMetasone Furoate (IMpurity)

Base Information

• Chemical Name: 21-Hydroxy DeschloroMoMetasone Furoate (IMpurity)
• CAS No.: 148596-90-1
• Molecular Formula: C₂₇H₃₁ClO₇
• Molecular Weight: 502.992
• Mol file: 148596-90-1.mol

Synonyms:

Chemical Property of 21-Hydroxy DeschloroMoMetasone Furoate (IMpurity)

Chemical Property:

• Melting Point: >200oC (dec.)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

21-HydroxyDeschloromometasoneFuroate(Impurity) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 21-Hydroxy Deschloromometasone Furoate (Mometasone EP Impurity H) is an impurity of Mometasone Furoate (M490000), a topical corticosteroid used as an anti-inflammatory. (21-Hydroxy Deschloromomtasone Furoate) Impurity of Mometasone Furoate (M490000), a topical corticosteroid used as an anti-inflammatory.

Technology Process of 21-Hydroxy DeschloroMoMetasone Furoate (IMpurity)

There total 5 articles about 21-Hydroxy DeschloroMoMetasone Furoate (IMpurity) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9α-chloro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate (83897-05-6) → C27H31ClO7 (148596-90-1)

Guidance literature:

With perchloric acid; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;

DOI:10.1016/j.steroids.2019.04.008

Reference yield:

16α-methyl-17α,21-dihydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate) 21-acetate (83880-61-9) → C27H31ClO7 (148596-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin / water; tetrahydrofuran / 10 h / 0 - 20 °C

2: perchloric acid / water; methanol; tetrahydrofuran / 24 h / 20 °C

With perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.steroids.2019.04.008

Reference yield:

17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate (10106-41-9) → C27H31ClO7 (148596-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / dichloromethane / 48 h / 5 - 20 °C

2: perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin / water; tetrahydrofuran / 10 h / 0 - 20 °C

3: perchloric acid / water; methanol; tetrahydrofuran / 24 h / 20 °C

With dmap; perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.steroids.2019.04.008

upstream raw materials:

16α-methyl-17α,21-dihydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate) 21-acetate

9α-chloro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate

17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate

Refernces