5-hydroxypomalidomide

Base Information

Chemical Name:5-hydroxypomalidomide
CAS No.:1547162-41-3
Molecular Formula:C₁₃H₁₁N₃O₅
Molecular Weight:289.247
Hs Code.:

Synonyms:

Suppliers and Price of 5-hydroxypomalidomide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione
100mg
$ 1540.00

TRC
4-Amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione
10mg
$ 195.00

Total 5 raw suppliers

Chemical Property of 5-hydroxypomalidomide

Chemical Property:

Boiling Point:633.0±55.0 °C(Predicted)
Density:1.677±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

4-Amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione is an impurity of Pomalidomide (P688200). Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.

Technology Process of 5-hydroxypomalidomide

There total 11 articles about 5-hydroxypomalidomide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 2686-86-4
3-aminopiperidine-2,6-dione hydrochloric acid salt

: 1451010-89-1
3-amino-4-hydroxyphthalic acid

: 1547162-41-3
5-hydroxypomalidomide

Guidance literature:: 3-aminopiperidine-2,6-dione hydrochloric acid salt; With triethylamine; at 20 ℃; for 4h;

3-amino-4-hydroxyphthalic acid; With acetic acid; at 120 ℃; for 2.33333h;

Reference yield:

: 1547163-02-9
4-amino-2-(2,6-dioxopiperidin-3-yl)-5-methoxy-isoindole-1,3-dione

: 1547162-41-3
5-hydroxypomalidomide

Guidance literature:: With boron tribromide;

Reference yield:

: 22479-95-4
dimethyl 4-hydroxyphthalate

: 1547162-41-3
5-hydroxypomalidomide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; nitric acid / 2 h / 20 °C / Cooling with ice

2.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

3.1: sodium hydroxide; water / ethanol / 70 °C

4.1: triethylamine / 4 h / 20 °C

4.2: 2.33 h / 120 °C

With sulfuric acid; palladium on activated charcoal; water; hydrogen; nitric acid; triethylamine; sodium hydroxide; In methanol; ethanol;