C₁₀H₁₀N₂O₃

Base Information

• Chemical Name: C₁₀H₁₀N₂O₃
• CAS No.: 857760-44-2
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Mol file: 857760-44-2.mol

Synonyms:

Chemical Property of C₁₀H₁₀N₂O₃

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

5-(4-Nitrophenyl)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₀N₂O₃

There total 24 articles about C₁₀H₁₀N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-[{3,5-bis(trifluoromethyl)benzoyl}oxy]-4-(4-nitrophenyl)butanamide → 5-(4-nitrophenyl)pyrrolidin-2-one (857760-44-2)

Guidance literature:

With C₂₂H₂₆ClIrN₂O₃; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In 2,2,2-trifluoroethanol; at 40 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.9b00791

Reference yield: 85.0%

3-(3-(4-nitrophenyl)propyl)-1,4,2-dioxazol-5-one → 5-(4-nitrophenyl)pyrrolidin-2-one (857760-44-2)

Guidance literature:

With C₂₂H₂₆ClIrN₂O₃; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1126/science.aap7503

Reference yield: 84.0%

3-(3-(4-nitrophenyl)propyl)-1,4,2-dioxazol-5-one → C10H10N2O3 (857760-44-2)

Guidance literature:

With C₄₈H₄₆N₆Ru⁽²⁺⁾*2BF₄^(1-); In 1,2-dichloro-benzene; at 4 ℃; for 30h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.9b09301

upstream raw materials:

(+/-)-5-phenyl-2-pyrrolidinone

(rac)-4-amino-4-phenylbutanoic acid

succinylbenzene

4-(4-nitrophenyl)butanoic acid

Refernces

• 1、 Xing, Qi,Chan, Chun-Ming,Yeung, Yiu-Wai,Yu, Wing-Yiu. "Ruthenium(II)-Catalyzed Enantioselective γ-Lactams Formation by Intramolecular C-H Amidation of 1,4,2-Dioxazol-5-ones". supporting information. p. 3849 - 3853. Retrieved 2019/04/25.
• 2、 Wang, Hao,Park, Yoonsu,Bai, Ziqian,Chang, Sukbok,He, Gang,Chen, Gong. "Iridium-Catalyzed Enantioselective C(sp3)-H Amidation Controlled by Attractive Noncovalent Interactions". . p. 7194 - 7201. Retrieved 2019/05/10.