N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide

Base Information

• Chemical Name: N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide
• CAS No.: 1504588-00-4
• Molecular Formula: C₂₃H₂₀ClN₃O
• Molecular Weight: 389.884
• Mol file: 1504588-00-4.mol

Synonyms:

Chemical Property of N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

NAB2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide

There total 5 articles about N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide (1504588-00-4)

Guidance literature:

With hydrogenchloride; iron; In water; butan-1-ol; at 110 ℃; for 1h; Sealed tube;

Reference yield:

C22H20ClN3O3 → N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide (1504588-00-4)

Guidance literature:

With hydrogenchloride; formic acid; benzamide; iron; In butan-1-ol; at 110 ℃; for 1h; Sealed tube;

DOI:10.1016/j.chembiol.2020.10.008

Reference yield:

N-(2-chlorobenzyl)-4-fluoro-3-nitrobenzamide → N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide (1504588-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water / 24 h / 110 °C / Sealed tube

2: benzamide; formic acid; iron; hydrogenchloride / butan-1-ol / 1 h / 110 °C / Sealed tube

With hydrogenchloride; formic acid; benzamide; iron; sodium hydrogencarbonate; In water; butan-1-ol;

DOI:10.1016/j.chembiol.2020.10.008

upstream raw materials:

2-CHLOROBENZYLAMINE

3-nitro-4-fluorobenzoic acid