6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

Base Information

Chemical Name:6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide
CAS No.:2284621-75-4
Molecular Formula:C₁₉H₂₁Cl₂N₇O₂
Molecular Weight:450.327
Hs Code.:

Synonyms:

Suppliers and Price of 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

There total 5 articles about 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: ethyl 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)hexanoate

: 2284621-75-4
6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; at 20 ℃;
DOI:10.1021/acs.jmedchem.8b01597

Reference yield:

: 106-47-8
4-chloro-aniline

: 2284621-75-4
6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / butan-1-ol / 3 h / 130 °C / Microwave irradiation

3: hydroxylamine potassium salt / methanol / 20 °C

With hydroxylamine potassium salt; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/acs.jmedchem.8b01597

Reference yield:

: ethyl 6-(4-((tert-butoxycarbonyl)amino)-1H-pyrazol-1-yl)-hexanoate

: 2284621-75-4
6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 20 °C

2: trifluoroacetic acid / butan-1-ol / 3 h / 130 °C / Microwave irradiation

3: hydroxylamine potassium salt / methanol / 20 °C

With hydrogenchloride; hydroxylamine potassium salt; trifluoroacetic acid; In methanol; ethyl acetate; butan-1-ol;
DOI:10.1021/acs.jmedchem.8b01597