trans-Clopidogrel Thiol Metabolite (Mixture of Diastereomers) Discontinued

Base Information

• Chemical Name: trans-Clopidogrel Thiol Metabolite (Mixture of Diastereomers) Discontinued
• CAS No.: 767612-34-0
• Molecular Formula: C₁₆H₁₈ClNO₄S
• Molecular Weight: 355.842
• Mol file: 767612-34-0.mol

Synonyms:

Chemical Property of trans-Clopidogrel Thiol Metabolite (Mixture of Diastereomers) Discontinued

Chemical Property:

• Melting Point: 67-71°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99.0% ^*data from raw suppliers

trans-ClopidogrelThiolMetabolite>85%(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: An active metabolite of Clopidogrel (C587250). trans-Clopidogrel Thiol Metabolite, is an active metabolite of Clopidogrel (C587250).

Technology Process of trans-Clopidogrel Thiol Metabolite (Mixture of Diastereomers) Discontinued

There total 87 articles about trans-Clopidogrel Thiol Metabolite (Mixture of Diastereomers) Discontinued which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(E)-2-(4-acetylmercapto)-1-(S)-1-(2-chlorophenyl)-2-methoxy-2-carbonylethylpiperidine-3-ethylene acid → R-361015 (767612-34-0)

Guidance literature:

In water; acetonitrile; at 25 ℃; for 2h; Irradiation;

Reference yield: 85.0%

2-[(3E)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-mercaptopiperidine-3-ylidene]acetic acid (767612-34-0) → R-361015 (767612-34-0)

Guidance literature:

In water; acetonitrile; at 25 ℃; for 2h; Irradiation;

Reference yield: 75.0%

(E)-2-(4-acetylmercapto)-1-(S)-1-(2-chlorophenyl)-2-methoxy-2-carbonylethylpiperidine-3-ethylene acid → 2-[(3E)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-mercaptopiperidine-3-ylidene]acetic acid (767612-34-0)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 15 ℃; for 10h;

upstream raw materials:

2-Oxoclopidogrel

(S)-(+)-clopidogrel

ethyl (E)-2-(4-hydroxy-1-tritylpiperidin-3-ylidene)acetate

1-triphenylmethyl-4-piperidone

Downstream raw materials:

C₂₅H₂₆ClNO₆S