Technology Process of 1-(2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)-N-methylmethanamine
There total 5 articles about 1-(2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)-N-methylmethanamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 2 h / 0 - 20 °C
2.1: caesium carbonate / acetonitrile / 4 h / 20 °C
3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 1.5 h / -78 - -40 °C / Inert atmosphere
3.2: 2 h / -78 °C / Inert atmosphere
4.1: methanol / 0.5 h / 25 °C
5.1: sodium tetrahydroborate / methanol / 1 h / 0 - 25 °C
With
sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; caesium carbonate;
In
tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00579
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / acetonitrile / 4 h / 20 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 1.5 h / -78 - -40 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
3.1: methanol / 0.5 h / 25 °C
4.1: sodium tetrahydroborate / methanol / 1 h / 0 - 25 °C
With
sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; caesium carbonate;
In
tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00579
