2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol

Base Information

• Chemical Name: 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol
• CAS No.: 850406-55-2
• Molecular Formula: C₁₁H₁₂ClNO
• Molecular Weight: 209.675
• Mol file: 850406-55-2.mol

Synonyms:

Chemical Property of 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

2-(5-Chloro-1-methyl-1H-indol-3-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol

There total 4 articles about 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-chloro-1-methyl-1H-indol-3-yl)-acetic acid (850406-54-1) + [1-(5-chloro-1-methyl-1H-indol-3-yl)-cyclopropyl]-carboxylic acid (850406-53-0) → 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol (850406-55-2) + [1-(5-chloro-1-methyl-1H-indol-3-yl)-cyclopropyl]-methanol (850406-48-3)

Guidance literature:

2-(5-chloro-1-methyl-1H-indol-3-yl)-acetic acid; [1-(5-chloro-1-methyl-1H-indol-3-yl)-cyclopropyl]-carboxylic acid; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃;

With hydrogenchloride; In tetrahydrofuran; water; for 0.5h;

Reference yield:

C16H24ClNOSi → 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol (850406-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.25 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; lithium hydroxide monohydrate / tetrahydrofuran; mineral oil / 0.5 h

With hydrogenchloride; lithium hydroxide monohydrate; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1039/c2ob26139a

Reference yield:

C17H26ClNOSi → 2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol (850406-55-2)

Guidance literature:

With hydrogenchloride; lithium hydroxide monohydrate; In tetrahydrofuran; mineral oil; for 0.5h;

DOI:10.1039/c2ob26139a

upstream raw materials:

2-(5-chloro-1-methyl-1H-indol-3-yl)-acetic acid

[1-(5-chloro-1-methyl-1H-indol-3-yl)-cyclopropyl]-carboxylic acid

2-(5-chloro-1H-indol-3-yl)ethanol