indirubin-3′-(3,4-dihydroxybutyl)oxime ether

Base Information

• Chemical Name: indirubin-3′-(3,4-dihydroxybutyl)oxime ether
• CAS No.: 854171-35-0
• Molecular Formula: C₂₀H₁₉N₃O₄
• Molecular Weight: 365.389
• Mol file: 854171-35-0.mol

Synonyms:

Chemical Property of indirubin-3′-(3,4-dihydroxybutyl)oxime ether

Chemical Property:

• Density: 1.44±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

IndirubinDerivativeE804 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Indirubin Derivative E804 is a cell-permeable inhibitor of Src-Stat3 signaling pathway.

Technology Process of indirubin-3′-(3,4-dihydroxybutyl)oxime ether

There total 5 articles about indirubin-3′-(3,4-dihydroxybutyl)oxime ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indirubin-3'-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]oxime ether → indirubin-3′-(3,4-dihydroxybutyl)oxime ether (854171-35-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.7b00324

Reference yield:

indirubin-3'-oxime (160807-49-8) → indirubin-3′-(3,4-dihydroxybutyl)oxime ether (854171-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / ethanol / 2 h / Reflux

2: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; N,N,N',N'-tetramethylguanidine; In ethanol; water;

DOI:10.1021/acs.jmedchem.7b00324

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → indirubin-3′-(3,4-dihydroxybutyl)oxime ether (854171-35-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / methanol / 5 h / 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride / pyridine / 3 h / Reflux

3: N,N,N',N'-tetramethylguanidine / ethanol / 2 h / Reflux

4: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium carbonate; N,N,N',N'-tetramethylguanidine; In pyridine; methanol; ethanol; water;

DOI:10.1021/acs.jmedchem.7b00324

upstream raw materials:

indirubin-3'-oxime

indole-2,3-dione

indirubin