2-(4-METHOXY-PHENYL)-MORPHOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-(4-METHOXY-PHENYL)-MORPHOLINE HYDROCHLORIDE
• CAS No.: 99985-89-4
• Molecular Formula: C₁₁H₁₅NO₂*ClH
• Molecular Weight: 229.707
• Mol file: 99985-89-4.mol

Synonyms:

Chemical Property of 2-(4-METHOXY-PHENYL)-MORPHOLINE HYDROCHLORIDE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-METHOXY-PHENYL)-MORPHOLINE HYDROCHLORIDE

There total 7 articles about 2-(4-METHOXY-PHENYL)-MORPHOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H21NO2 → C11H15NO2*ClH (99985-89-4)

Guidance literature:

C₁₈H₂₁NO₂; With carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 20 ℃;

With methanol; Reflux;

DOI:10.1016/j.bmcl.2013.09.020

Reference yield:

C18H19NO3 → C11H15NO2*ClH (99985-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 20 °C

2.2: Reflux

With lithium borohydride; chloro-trimethyl-silane; carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2013.09.020

Reference yield:

2-chloro-1-(4-methoxyphenyl)ethanone (2196-99-8) → C11H15NO2*ClH (99985-89-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: borane-THF; potassium hydroxide; (S)-Corey-Bakshi-Shibata oxazaborolidine / water; diethyl ether / -30 °C

2.1: potassium hydroxide / water; diethyl ether / 20 °C

3.1: 80 °C

4.1: sodium hydroxide / dichloromethane; water / 20 °C

5.1: potassium hydroxide / isopropyl alcohol / 20 °C

6.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 20 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 20 °C

7.2: Reflux

With lithium borohydride; chloro-trimethyl-silane; borane-THF; carbonochloridic acid 1-chloro-ethyl ester; potassium hydroxide; sodium hydroxide; (S)-Corey-Bakshi-Shibata oxazaborolidine; In tetrahydrofuran; diethyl ether; dichloromethane; water; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.09.020

upstream raw materials:

2-chloro-1-(4-methoxyphenyl)ethanone

(S)-1-chloro-2-hydroxy-2-(p-methoxyphenyl)ethane