Technology Process of urolithin M7
There total 13 articles about urolithin M7 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
for 72h;
DOI:10.1021/acs.joc.7b00256
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: piperidine / benzene / 3 h / Reflux; azeotropic removal of water
2.1: water; benzene / 168 h / 80 °C / Inert atmosphere
3.1: sodium hydroxide / ethanol; water / 1 h / 100 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere
4.2: 12 h / Reflux; Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; hexanes / 96 h / 0 - 20 °C / Inert atmosphere
6.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 96 h / 20 °C
7.1: hydrogen iodide / water / 0.5 h / 127 °C
With
piperidine; tetrakis(triphenylphosphine) palladium(0); hydrogen iodide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; hexanes; ethanol; dichloromethane; water; mineral oil; benzene;
2.1: inverse electron-demand Diels-Alder (IEDDA) reaction / 6.1: Baeyer-Villiger oxidation;
DOI:10.1055/s-0030-1261203