3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid

Base Information

Chemical Name:3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid
CAS No.:860787-38-8
Molecular Formula:C₁₄H₁₇F₂NO₄
Molecular Weight:301.29
Hs Code.:
DSSTox Substance ID:DTXSID901147484
Mol file:860787-38-8.mol

Synonyms:860787-38-8;3-[(tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid;3-{[(tert-butoxy)carbonyl]amino}-3-(2,4-difluorophenyl)propanoic acid;3-(2,4-difluorophenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic Acid;3-((TERT-BUTOXYCARBONYL)AMINO)-3-(2,4-DIFLUOROPHENYL)PROPANOIC ACID;3-([(tert-Butoxy)carbonyl]amino)-3-(2,4-difluorophenyl)propanoic acid;SCHEMBL16680101;DTXSID901147484;AKOS005081557;AB23527;AB23557;CS-0262173;EN300-816703;SR-01000307527;12X-0812;SR-01000307527-1;Z1201019790;3-{[(tert-butoxy)carbonyl]amino}-3-(2,4-difluorophenyl)propanoicacid;(R)-3-TERT-BUTOXYCARBONYLAMINO-3-(2,4-DIFLUORO-PHENYL)-PROPIONIC ACID;(S)-3-TERT-BUTOXYCARBONYLAMINO-3-(2,4-DIFLUORO-PHENYL)-PROPIONIC ACID;beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4-difluorobenzenepropanoic acid

Suppliers and Price of 3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-[(tert-Butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid
5g
$ 7343.00

Matrix Scientific
3-[(tert-Butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid
1g
$ 1836.00

Matrix Scientific
3-[(tert-Butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid
500mg
$ 918.00

AK Scientific
3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoicacid
250mg
$ 310.00

Total 4 raw suppliers

Chemical Property of 3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid

Chemical Property:

Boiling Point:415.3±45.0 °C(Predicted)
PKA:4.30±0.10(Predicted)
Density:1.268±0.06 g/cm3(Predicted)
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:301.11256435
Heavy Atom Count:21
Complexity:384

Purity/Quality:

97% ^*data from raw suppliers

3-[(tert-Butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC(=O)O)C1=C(C=C(C=C1)F)F

Technology Process of 3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid

There total 2 articles about 3-[(Tert-butoxycarbonyl)amino]-3-(2,4-difluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (R)-3-amino-3-(2,4-difluorophenyl)propanoic acid

: 860787-38-8
(R)-3-tert-butoxycarbonylamino-3-(2,4-difluoro-phenyl)propionic acid

Guidance literature:: With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 19h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 412925-23-6
rac-3-amino-3-(2,4-difluorophenyl)propanoic acid

: 860787-38-8
3-((tert-butoxycarbonyl)amino)-3-(2,4-difluorophenyl)propanoic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

: 860787-38-8
3-((tert-butoxycarbonyl)amino)-3-(2,4-difluorophenyl)propanoic acid

: tert-butyl 3-(4-bromo-3-fluorophenyl)-5-(2,4-difluorophenyl)-2-oxoimidazolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 16.5 h / 20 - 75 °C

2: N,N`-dimethylethylenediamine; cesium fluoride; copper(l) iodide / ethyl acetate / 20 h / 20 °C

With copper(l) iodide; diphenyl phosphoryl azide; triethylamine; cesium fluoride; N,N`-dimethylethylenediamine; In ethyl acetate; toluene;