AR-C118925

Base Information

Chemical Name:AR-C118925
CAS No.:216657-60-2
Molecular Formula:C₂₈H₂₃N₇O₃S
Molecular Weight:537.602
Hs Code.:

Synonyms:

Suppliers and Price of AR-C118925

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AR-C 118925XX
5mg
$ 602.00

TRC
AR-C118925XX
2.5mg
$ 185.00

Total 1 raw suppliers

Chemical Property of AR-C118925

Chemical Property:

Density:1.51±0.1 g/cm3(Predicted)

Purity/Quality:

≥97% by HPLC ^*data from raw suppliers

AR-C 118925XX ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses AR-C 118925XX is a potent and selective non-nucleotide antagonist of the P2Y2 receptor discovered using the endogenous P2Y2R agonist UTP as the chemical starting point.

Technology Process of AR-C118925

There total 11 articles about AR-C118925 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 4418-61-5
5-aminotetrazole

: 5-{[5-(2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-2-furancarboxylic acid

: 216657-60-2
AR-C118925

Guidance literature:: With benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1007/s11302-016-9542-3

Reference yield:

: 88-14-2
2-furanoic acid

: 216657-60-2
AR-C118925

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane; ethylbenzene / 0.25 h / -70 - -60 °C / Cooling with acetone-dry ice

1.2: 1 °C

2.1: N,N-dimethyl-formamide / 48 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 70 °C

4.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium sulfate / 0.17 h / 140 °C / Sealed tube

4.2: 1 h / 140 °C

5.1: Lawessons reagent / 1,4-dioxane / 3 h / 120 °C

6.1: lithium hydroxide / water; 1,4-dioxane; methanol / 1 h / 20 °C

7.1: benzotriazol-1-ol; diisopropyl-carbodiimide / tetrahydrofuran / 6 h / 20 °C

With Lawessons reagent; ammonium sulfate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzotriazol-1-ol; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hydroxide; diisopropyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; hexane; ethylbenzene; water; N,N-dimethyl-formamide;
DOI:10.1007/s11302-016-9542-3

Reference yield:

: 1917-15-3
5-methylfuran-2-carboxylic acid

: 216657-60-2
AR-C118925

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 48 h / 20 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 70 °C

3.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium sulfate / 0.17 h / 140 °C / Sealed tube

3.2: 1 h / 140 °C

4.1: Lawessons reagent / 1,4-dioxane / 3 h / 120 °C

5.1: lithium hydroxide / water; 1,4-dioxane; methanol / 1 h / 20 °C

6.1: benzotriazol-1-ol; diisopropyl-carbodiimide / tetrahydrofuran / 6 h / 20 °C

With Lawessons reagent; ammonium sulfate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzotriazol-1-ol; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1007/s11302-016-9542-3