1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole
• CAS No.: 1809031-84-2
• Molecular Formula: C₁₄H₉IN₄O₂
• Molecular Weight: 392.156
• Mol file: 1809031-84-2.mol

Synonyms:

Chemical Property of 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

P62-mediatedmitophagyinducer >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole

There total 2 articles about 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-nitrobromobenzene (585-79-5) → 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole (1809031-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

2: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

3: copper(II) sulfate; ascorbic acid / water; tert-butyl alcohol / 0.52 h / 100 - 130 °C / Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; copper(II) sulfate; diethylamine; ascorbic acid; In methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: |Sonogashira Cross-Coupling;

DOI:10.1021/acs.jmedchem.5b00602

Reference yield:

m-iodonitrobenzene (645-00-1) → 1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole (1809031-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Sealed tube

2: methanol; potassium carbonate / 22 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; ascorbic acid / water; tert-butyl alcohol / 0.5 h / 130 °C / Microwave irradiation

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; potassium carbonate; triethylamine; ascorbic acid; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/acs.jmedchem.9b00723

upstream raw materials:

m-nitrobromobenzene

m-iodonitrobenzene