Technology Process of 6-BENZYLOXY-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
There total 1 articles about 6-BENZYLOXY-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-benzyloxy-1H-indole;
With
iodine; potassium hydroxide;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.166667h;
di-tert-butyl dicarbonate;
With
dmap;
In
dichloromethane;
at 20 ℃;
for 1.5h;
stereoselective reaction;
DOI:10.1002/anie.201604754
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: C24H30ClCoN2O4; phenylsilane / benzene / 60 °C
2.2: 5 h / 25 °C
With
phenylsilane; C24H30ClCoN2O4; isopropylmagnesium chloride;
In
tetrahydrofuran; benzene;
DOI:10.1002/anie.201604754
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: C24H30ClCoN2O4; phenylsilane; oxygen / benzene / 0.25 h / 60 °C
With
phenylsilane; C24H30ClCoN2O4; isopropylmagnesium chloride; oxygen;
In
tetrahydrofuran; benzene;
DOI:10.1002/anie.201604754
