3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Base Information

Chemical Name:3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid
CAS No.:2166487-21-2
Molecular Formula:C₃₁H₃₉FN₆O₆S₂
Molecular Weight:674.818
Hs Code.:

3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Synonyms:

Suppliers and Price of 3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

There total 5 articles about 3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl ((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)carbamate

: 4314-19-6
bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 2166487-21-2
3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Guidance literature:: tert-butyl ((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)carbamate; With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione; tert-butyl 3-aminopropanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Further stages; Inert atmosphere;
DOI:10.1002/anie.201709050

Reference yield:

: C₃₄H₄₅N₅O₆

: 2166487-21-2
3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 45 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With chlorotriisopropylsilane; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1002/anie.201709050

Reference yield:

: 13139-14-5
Boc-Trp-OH

: 2166487-21-2
3-(3-((S)-6-(((S)-1-(cyclobutylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-((3-fluorophenyl)sulfonamido)-6-oxohexyl)thioureido)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane / 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 45 °C

4.2: 2 h / 20 °C

5.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.2: 0 °C / Inert atmosphere

With chlorotriisopropylsilane; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1002/anie.201709050