5-brom-2-methylsulfanylmethylpyridine

Base Information

• Chemical Name: 5-brom-2-methylsulfanylmethylpyridine
• CAS No.: 1566292-79-2
• Molecular Formula: C₇H₈BrNS
• Molecular Weight: 218.117
• Mol file: 1566292-79-2.mol

Synonyms:

Chemical Property of 5-brom-2-methylsulfanylmethylpyridine

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

5-Bromo-2-methylsulfanylmethyl-pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-brom-2-methylsulfanylmethylpyridine

There total 2 articles about 5-brom-2-methylsulfanylmethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium thiomethoxide (5188-07-8) + 5-bromo-2-(chloromethyl)pyridine (168823-76-5) → 5-brom-2-methylsulfanylmethylpyridine (1566292-79-2)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 2h;

Reference yield:

(5-bromopyridin-2-yl)methanol (88139-91-7) → 5-brom-2-methylsulfanylmethylpyridine (1566292-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 2 h / 0 °C

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

5-brom-2-methylsulfanylmethylpyridine (1566292-79-2) → 2,2-difluoro-N-{(1R,2R)-1-fluoromethyl-2-hydroxy-2-[4-(6(S-methylsulfonimidoylmethyl)pyridine-3-yl)phenyl]ethyl}acetamide

Guidance literature:

Multi-step reaction with 5 steps

1: sodium periodate / methanol; water / 5 h / 0 - 20 °C

2: magnesium oxide; dirhodium tetraacetate / dichloromethane / 16 h / 0 - 20 °C

3: potassium carbonate; methanol / 0.5 h / 20 °C

4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 80 °C

5: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dirhodium tetraacetate; sodium periodate; magnesium oxide; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water;

upstream raw materials:

sodium thiomethoxide

5-bromo-2-(chloromethyl)pyridine

(5-bromopyridin-2-yl)methanol