[3-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl phenyl ether

Base Information

• Chemical Name: [3-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl phenyl ether
• CAS No.: 791824-26-5
• Molecular Formula: C₁₆H₁₁FN₄OS
• Molecular Weight: 326.354
• Mol file: 791824-26-5.mol

Synonyms:

Chemical Property of [3-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl phenyl ether

Chemical Property:

• PKA: -1.06±0.50(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl phenyl ether

There total 5 articles about [3-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-amino-5-(3-fiuorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiol (61019-25-8) + 2-phenoxyacetic acid (122-59-8) → 3-(4-fluorophenyl)-6-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (791824-26-5)

Guidance literature:

With dmap; tetrabutylammomium bromide; trichlorophosphate; Microwave irradiation; Heating;

DOI:10.1039/c5ra19334f

Reference yield:

1-(p-fluorophenylcarbonyl)imidazole (90172-63-7) → 3-(4-fluorophenyl)-6-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (791824-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / tetrahydrofuran / 20 °C

2: potassium hydroxide / ethanol / 20 °C

3: hydrazine hydrate / water / 20 °C / Reflux

4: tetrabutylammomium bromide; dmap; trichlorophosphate / Microwave irradiation; Heating

With dmap; tetrabutylammomium bromide; hydrazine hydrate; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water;

DOI:10.1039/c5ra19334f

Reference yield:

4-fluorobenzoyl hydrazide (456-06-4) → 3-(4-fluorophenyl)-6-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (791824-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 20 °C

2: hydrazine hydrate / water / 20 °C / Reflux

3: tetrabutylammomium bromide; dmap; trichlorophosphate / Microwave irradiation; Heating

With dmap; tetrabutylammomium bromide; hydrazine hydrate; potassium hydroxide; trichlorophosphate; In ethanol; water;

DOI:10.1039/c5ra19334f

upstream raw materials:

1-(p-fluorophenylcarbonyl)imidazole

4-amino-5-(3-fiuorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiol

2-phenoxyacetic acid

4-fluorobenzoyl hydrazide