N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide

Base Information

• Chemical Name: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide
• CAS No.: 2165325-42-6
• Molecular Formula: C₁₈H₁₅F₃N₄O₄
• Molecular Weight: 408.337
• Mol file: 2165325-42-6.mol

Synonyms:

Chemical Property of N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

VU 6010608 NEW ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide

There total 2 articles about N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1,2,4-Triazole (288-88-0) + N-(2-bromo-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide → N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide (2165325-42-6)

Guidance literature:

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00429

Reference yield:

2-bromo-5-(trifluoromethoxy)benzenamine (887267-47-2) + Veratric acid (93-07-2) → N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide (2165325-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate / dichloromethane / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

2: potassium phosphate; copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 2: |Ullmann Condensation;

DOI:10.1021/acsmedchemlett.7b00429

upstream raw materials:

1,2,4-Triazole

2-bromo-5-(trifluoromethoxy)benzenamine

Veratric acid