5-hydroxy-N-formylkynurenine

Base Information

• Chemical Name: 5-hydroxy-N-formylkynurenine
• CAS No.: 73637-65-7
• Molecular Formula: C₁₁H₁₂N₂O₅
• Molecular Weight: 252.227
• Mol file: 73637-65-7.mol

Synonyms:

Chemical Property of 5-hydroxy-N-formylkynurenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-N-formylkynurenine

There total 3 articles about 5-hydroxy-N-formylkynurenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → 5-hydroxy-N-formylkynurenine (73637-65-7) + 3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-2-carboxylic acid (35169-97-2)

Guidance literature:

With dimethylsulfide; oxygen; methylene blue; Yield given. Multistep reaction; 1.) H₂O, ethanol, from O to 5 deg C, pH 7.7, irrad., 1.5 h, 2.) H₂O, ethanol, overnight;

Reference yield:

L-5-HTP (4350-09-8,4298-20-8) → 5-hydroxy-N-formylkynurenine (73637-65-7)

Guidance literature:

With recombinant human indoleamine 2,3-dioxygenase; methylene blue; L-dehydroascorbic acid; bovine liver catalase; In aq. phosphate buffer; at 25 ℃; for 0.5h; pH=6.5; Kinetics; Enzymatic reaction;

DOI:10.1007/s00726-014-1766-3

Reference yield:

3a,5-dihydroxypyrroloindole (89838-30-2) → 5-hydroxy-N-formylkynurenine (73637-65-7)

Guidance literature:

With oxygen; for 2h; Yield given; Ambient temperature;

upstream raw materials:

3a,5-dihydroxypyrroloindole

L-Tryptophan

L-5-HTP

Downstream raw materials:

5-hydroxykynurenine