3-benzoylcyclobutanecarboxaldehyde

Base Information

• Chemical Name: 3-benzoylcyclobutanecarboxaldehyde
• CAS No.: 126109-98-6
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.226
• Mol file: 126109-98-6.mol

Synonyms:

Chemical Property of 3-benzoylcyclobutanecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzoylcyclobutanecarboxaldehyde

There total 3 articles about 3-benzoylcyclobutanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenylbicyclo<2.1.1>hex-2-ene (126109-97-5) → 3-benzoylcyclobutanecarboxaldehyde (126109-98-6)

Guidance literature:

With dimethylsulfide; ozone; Yield given. Multistep reaction; 1) 3 min, -78 deg C;

DOI:10.1021/jo00289a053

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 3-benzoylcyclobutanecarboxaldehyde (126109-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium / in THF

2: 1) sodium hydride (50percent), 2) carbon disulfide, 3) methyl iodide / 1) ether, 15 min, 2) 0.5 h, reflux, 3) 12 h, reflux

3: 1) ozon, 2) dimethyl sulfide / 1) 3 min, -78 deg C

With carbon disulfide; dimethylsulfide; sodium hydride; ozone; magnesium; methyl iodide;

DOI:10.1021/jo00289a053

Reference yield:

2-hydroxy-2-phenylbicyclo<2.1.1>hexane (125642-76-4) → 3-benzoylcyclobutanecarboxaldehyde (126109-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) sodium hydride (50percent), 2) carbon disulfide, 3) methyl iodide / 1) ether, 15 min, 2) 0.5 h, reflux, 3) 12 h, reflux

2: 1) ozon, 2) dimethyl sulfide / 1) 3 min, -78 deg C

With carbon disulfide; dimethylsulfide; sodium hydride; ozone; methyl iodide;

DOI:10.1021/jo00289a053

upstream raw materials:

2-phenylbicyclo<2.1.1>hex-2-ene

bromobenzene

2-hydroxy-2-phenylbicyclo<2.1.1>hexane